C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response
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چکیده
منابع مشابه
SnapShot: FMRP Interacting Proteins
The Fragile X syndrome, caused by the absence or mutation of fragile X mental retardation protein, FMRP, is a the common component of inherited intellectual disability and autism. This SnapShot surveys the protein interaction partners of FMRP, focusing on the cellular pathways in which they are involved.
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Author contributions: R.L.F., T.J.W., C.K.T., H.-H.L., and H.T.C. designed research; R.L.F., T.J.W., C.K.T., and H.-H.L. performed research; R.L.F., T.J.W., C.K.T., and H.-H.L. analyzed data; R.L.F. and H.T.C. wrote the paper. Funding: NEI EY011261 Funding: NIEHS K99ES022992 Funding: NINDS F32NS071807 Funding: NIGM T34GM087193 Funding: DOD | U.S. Army | U.S. Army Materiel Command (AMC) 10000675...
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Thioredoxin-interacting protein (Txnip) regulates intracellular redox state and prompts oxidative stress by binding to and inhibiting Thioredoxin (Trx). In addition, via a Trx-independent mechanism, Txnip regulates glucose metabolism and thus maintains intracellular glucose levels. Previously, we found Txnip mRNA highly expressed in immature germinal vesicle (GV) oocytes, but currently there is...
متن کاملTdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.
Tudor domains are widespread among proteins involved in RNA metabolism, but only in a few cases their cellular function has been analyzed in detail. Here, we report on the characterization of the ubiquitously expressed Tudor domain containing protein Tdrd3. Apart from its Tudor domain, we show that Tdrd3 possesses an oligosaccharide/nucleotide binding fold (OB-fold) and an ubiquitin associated ...
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Defective immune system function is implicated in autism spectrum disorders, including Fragile X syndrome. In this issue, O'Connor et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607093) demonstrate that phagocytic activity of systemic immune cells is compromised in a Drosophila melanogaster model of Fragile X, highlighting intriguing new mechanistic connections between FMRP, innate ...
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ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1245503